Hey i know you! LOL....anyways, i would say if you you can play man to man and get a strong rating in both ID and OD then you will be just fine. It all depends on the league you get put into though. As far as skills go for your guards you should be good with Sensational and your back-ups at Prominant. With Centers I would say around Tremendous ID. But also keep in mind those skills will just keep you in the middle of the pack so if you want to be in the top 3 then go above those skills.
Also, keep in mind that if you get put into a league that is more dominate in Bigs then guards then your Big's defense should be a little better and Guards defense could be a little worse. The same goes the other way around too.