So after looking back at it and actually reading your post, the one thing that you didn't mention was your SG match-up. I think that is pretty much what lost the game for you (if you do not consider free throws). Maybe I am wrong, but my experience is that run and gun puts a lot of focus on your SG in terms of shot selection. Having a really crap match-up at SG really bogs your offense down.
Also, back to the match-ups. As I said, run and gun puts focus on your SG and to a lesser extent your PG and SF (I think usually SF is the least of the three, but it often depends on flow skills and match-ups, too). NEP won the match-up at SG by a significant margin. He lost the PG and SF match-ups, but not by as big a margin. But the biggest thing was he got the most shots from his best match-up, SG.
Diefenbach took the majority of the shots for NEP so I am not surprised he took the most FT shots. I am guessing experience was some factor in his %, I think you took a lot of fouls in overtime when the game was pretty much over.
Anyhow, I think the fact that Infanzón took 17 shots in a run and gun goes to show that your offense had some issues in this game finding the right match-ups.
Run of the Mill Canadian Manager