People in my league (with top teams) hate ISOs. Apparently when there is no clear mismatch and you go against very good defenses (for your level of offense) the shot selection is not as 'reasonable' as in other tactics.
NTs have been widely using ISOs for some time now, and it does look like overcoming strong defenses (at least getting to nice percentages vs. the defense level in front).
(32376)(32391)A main difference with Patient I see then is the shot distribution, since there's no previously appointed position.
I also think the engine selects the isolated player on a play-by-play basis, which would contribute to the balanced.
I guess the conclusion to be successful with ISOs is, basically, to train perimeter players in inside skills, and viceversa. Then obviously supported by 5 players with DR-HN and also PS as an extra.